Renal dysfunction in cirrhosis
نویسندگان
چکیده
منابع مشابه
Renal and circulatory dysfunction in liver cirrhosis. Pathogenesis and treatment
Sodium Retention Sodium retention is probably the most common renal function abnormality in patients with cirrhosis and ascites and plays a key role in the pathophysiology of ascites and edema formation. It is the first manifestation of renal impairment cirrhotics develop. It appears before ascites formation, impaired free water excretion and functional renal failure (Figure 1). This observatio...
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Nitric oxide (NO) has diverse physiological and pathophysiological effects. The roles of NO in the renal and cardiac dysfunction found in cirrhosis are reviewed. In the kidneys of experimental animals with cirrhosis, several lines of evidence speak in favour of an enhanced production of NO, through the activation of both endothelial constitutive and inducible isoforms of NO synthase. In contras...
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The short-term mortality of cirrhotic patients who develop renal dysfunction remains unacceptably high, and as such the treatment of this condition is an unmet need. Although features of kidney injury are well recognized in these patients, the pathophysiology is complex and not completely understood. Improved understanding of the pathophysiological mechanisms involved in renal dysfunction occur...
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From the Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, and Institut d’Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Catalonia, Spain (P.G.); and the Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora (R.W.S.). Address reprint r...
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ژورنال
عنوان ژورنال: Current Opinion in Gastroenterology
سال: 2015
ISSN: 0267-1379
DOI: 10.1097/mog.0000000000000168